Protein Details: Glutamate receptor 3

Protein ID

ICDB_Pro_0524

Protein Name

Glutamate receptor 3

Gene Name

GRIA3; GluA3; GLUR3; GLURC

Organism

Homo sapiens (Human)

Length

894 amino acids

AlphaFoldDB

AF-P42263-F1-model_v4.pdb

Function

Ionotropic glutamate receptor that functions as a ligand-gated cation channel;gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA);quisqualic acid;and kainic acid (By similarity). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission by inducing long-term potentiation (By similarity). Binding of the excitatory neurotransmitter L-glutamate induces a conformation change;leading to the opening of the cation channel;and thereby converts the chemical signal to an electrical impulse upon entry of calcium. The receptor then desensitizes rapidly and enters a transient inactive state;characterized by the presence of bound agonist. In the presence of CACNG8;shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

Sequence

MARQKKMGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTDADVQFVIQMRPALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSASSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 508; /ligand="L-glutamate"; BINDING 510; /ligand="L-glutamate"; BINDING 515; /ligand="L-glutamate"; BINDING 686; /ligand="L-glutamate"; BINDING 687; /ligand="L-glutamate"; BINDING 737; /ligand="L-glutamate"

Disease

Intellectual Developmental Disorder;X-Linked;Syndromic;Wu Type and Syndromic X-Linked Intellectual Disability

Location

DOI ID

10.1016/0167-4781(94)90090-6; 10.1006/geno.1999.6032; 10.1002/(sici)1096-8628(20000103)90:1<69::aid-ajmg12>3.3.co;2-n; 10.1038/nature03440; 10.1016/j.neuron.2010.11.026; 10.1186/1750-1172-9-49; 10.1073/pnas.0708699104; 10.1055/s-0038-1668141

RefSeq

NP_000819.3 [P42263-1]; NP_015564.4 [P42263-2]